Targeting Carbohydrate Metabolism in Leishmania

Grant number: 1100000 | Funding period: 2016 - 2019

Completed

Abstract

There is an urgent need to develop new drugs to treat human leishmaniasis, a disease that causes debilitating and life-threatening diseases in millions of people worldwide. This project will investigate whether it is possible to develop a new generation of drugs that target a novel metabolic pathway in these parasites that we have shown to be essential for virulence.

Related publications (3)

Analysis of the Physiological and Metabolic State of Leishmania Using Heavy Water Labeling

J Kloehn, MJ McConville

2020-01-01

This protocol describes the use of heavy water (<sup>2</sup>H<inf>2</inf>O) labeling to determine the growth rate and metabolic st..

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

MF Sernee, JE Ralton, TL Nero, LF Sobala, J Kloehn, MA Vieira-Lara, SA Cobbold, L Stanton, DEV Pires, E Hanssen, A Males, T Ward, LM Bastidas, PL van der Peet, MW Parker, DB Ascher, SJ Williams, GJ Davies, MJ McConville

2019-09-11

Parasitic protists belonging to the genus Leishmania synthesize the non-canonical carbohydrate reserve, mannogen, which is compose..

DExSI: A new tool for the rapid quantitation of 13 C-labelled metabolites detected by GC-MS

MJ Dagley, MJ McConville

2018-06-01

Stable isotope directed metabolomics is increasingly being used to measure metabolic fluxes in microbial, plant and animal cells. ..

University of Melbourne Researchers

Malcolm McConville

Spencer Williams